[PDF] Organic Chemistry with a Biological Emphasis Volume II by Tim Soderberg Book Free Download


Organic Chemistry with a Biological Emphasis Volume II

Download Organic Chemistry with a Biological Emphasis Volume II by Tim Soderberg Book PDF. The traditional approach to teaching Organic Chemistry, taken by most of the textbooks that are currently available, is to focus primarily on the reactions of laboratory synthesis, with much less discussion – in the central chapters, at least – of biological molecules and reactions. This is despite the fact that, in many classrooms, a majority of students are majoring in Biology or Health Sciences rather than in Chemistry, and are presumably taking the course in order to learn about the chemistry that takes place in living things.

In an effort to address this disconnect, I have developed a textbook for a two-semester, sophomore-level course in Organic Chemistry in which biological chemistry takes center stage. For the most part, the text covers the core concepts of organic structure, structure determination, and reactivity in the standard order. What is different is the context: biological chemistry is fully integrated into the explanation of central principles, and as much as possible the in-chapter and end-of-chapter problems are taken from the biochemical literature. Many laboratory synthesis reactions are also covered, generally in parallel with their biochemical counterparts – but it is intentionally the biological chemistry that comes first.

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“Organic Chemistry with a Biological Emphasis Volume II by Tim Soderberg Book Free Download”

Organic Chemistry with a Biological Emphasis Volume I by Tim Soderberg Book Free Download
Organic Chemistry with a Biological Emphasis Volume I by Tim Soderberg Book Free Download

Book Details:

Title Of The Book Organic Chemistry with a Biological Emphasis Volume II
Author’s Name Tim Soderberg
Publishers University of Minnesota Morris
File Size 32.3 MB
File Type PDF

Table Of Content:

Chapter 9: Phosphate transfer reactions

  • Section 1: Overview of phosphate groups
  • Section 2: Phosphate transfer reactions – an overview
  • Section 3: ATP, the principal phosphate group donor
  • Section 4: Phosphorylation of alcohols
  • Section 5: Phosphorylation of carboxylates
  • Section 6: Hydrolysis of organic phosphates
  • Section 7: Phosphate diesters in DNA and RNA
  • Section 8: The organic chemistry of genetic engineering

Chapter 10: Nucleophilic carbonyl addition reactions

  • Section 1: Nucleophilic additions to aldehydes and ketones: an overview
  • Section 2: Hemiacetals, hemiketals, and hydrates
  • Section 3: Acetals and ketals
  • Section 4: N-glycosidic bonds
  • Section 5: Imines
  • Section 5: A look ahead: addition of carbon and hydride nucleophiles to carbonyls

Chapter 11: Nucleophilic acyl substitution reactions

  • Section 1: Carboxylic acid derivatives
  • Section 2: The nucleophilic acyl substitution mechanism
  • Section 3: The relative reactivity of carboxylic acid derivatives
  • Section 4: Acyl phosphates
  • Section 5: Formation of thioesters, esters, and amides
  • Section 6: Hydrolysis of thioesters, esters, and amides
  • Section 7: Protein synthesis on the ribosome
  • Section 8: Nucleophilic substitution at activated amides and carbamides
  • Section 9: Nucleophilic acyl substitution reactions in the laboratory
  • Section 10: A look ahead: acyl substitution reactions with a carbanion or hydride ion nucleophile

Chapter 12: Reactions at the α-carbon, part I

  • Section 1: Review of acidity at the α-carbon
  • Section 2: Isomerization at the α-carbon
  • Section 3: Aldol addition
  • Section 4: α-carbon reactions in the synthesis lab – kinetic vs. thermodynamic alkylation products

Interchapter: Predicting multistep pathways – the retrosynthesis approach
Chapter 13: Reactions at the α-carbon, part II

  • Section 1: Decarboxylation
  • Section 2: An overview of fatty acid metabolism
  • Section 3: Claisen condensation
  • Section 4: Conjugate addition and elimination
  • Section 5: Carboxylation

Chapter 14: Electrophilic reactions

  • Section 1: Electrophilic addition to alkenes
  • Section 2: Elimination by the E1 mechanism
  • Section 3: Electrophilic isomerization
  • Section 4: Electrophilic substitution
  • Section 5: Carbocation rearrangements

Chapter 15: Oxidation and reduction reactions

  • Section 1: Oxidation and reduction of organic compounds – an overview
  • Section 2: Oxidation and reduction in the context of metabolism
  • Section 3: Hydrogenation of carbonyl and imine groups
  • Section 4: Hydrogenation of alkenes and dehydrogenation of alkanes
  • Section 5: Monitoring hydrogenation and dehydrogenation reactions by UV spectroscopy
  • Section 6: Redox reactions of thiols and disulfides
  • Section 7: Flavin-dependent monooxygenase reactions: hydroxylation, epoxidation, and theBaeyer-Villiger oxidation
  • Section 8: Hydrogen peroxide is a harmful ‘Reactive Oxygen Species’

Chapter 16: Radical reactions

  • Section 1: Overview of single-electron reactions and free radicals
  • Section 2: Radical chain reactions
  • Section 3: Useful polymers formed by radical chain reactions
  • Section 4: Destruction of the ozone layer by a radical chain reaction
  • Section 5: Oxidative damage to cells, vitamin C, and scurvy
  • Section 6: Flavin as a one-electron carrier

Chapter 17: The organic chemistry of vitamins

  • Section 1: Pyridoxal phosphate (Vitamin B6)
  • Section 2: Thiamine diphosphate (Vitamin B1)
  • Section 3: Thiamine diphosphate, lipoamide and the pyruvate dehydrogenase reaction
  • Section 4: Folate

About the Book:

Tim Soderberg teaches Organic and Bioorganic Chemistry at UMM, as well as General Chemistry labs. He received a B.A. in English from Amherst College in 1987, and a California teaching credential from San Francisco State University in 1989. After teaching English as a Second Language in Tokyo, Japan for about five years, he returned to the United States and enrolled at Sonoma State University where he completed all of the undergraduate Chemistry, Calculus, and Physics courses necessary to enter a graduate Chemistry program. He came to UMM in the Fall of 2000 after receiving his Ph.D. in Biological Chemistry from the University of Utah under the direction of Professor C. Dale Poulter. His graduate research focused on the enzymology of two prenyltransferase enzymes: one that modifies tRNA, and one that is involved in the early biosynthesis of ether-linked membrane lipids in archaea. His research at UMM focused on characterization of enzymes in the pentose phosphate pathway in Archaea.

“Organic Chemistry with a Biological Emphasis Volume II by Tim Soderberg PDF File”

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